Antihyperalgesic effects of Meteorin in the rat chronic constriction injury model: a replication study
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چکیده
منابع مشابه
Microinjection of calcitonin in midbrain periaqueductal gray attenuates hyperalgesia in a chronic constriction injury rat model
Objective(s): As heat, pain is one of the most common clinical symptoms. Generally, calcitonin (CT) is prescribed as an analgesic agent for the treatment of pain, especially for the pain caused by osteoporosis or primary and metastatic bone tumor. However, the detailed mechanism remains unknown.Materials and Methods: In this study, chronic constriction injury (CCI) rat model was created, and ho...
متن کاملP8: Endocannabinoid System Mediate the Effects of Crocin on Development of Neuropathic Pain in a Rat Model of Chronic Constriction Injury
Neuropathic pain involves injury or alteration of the normal sensory and modulatory nervous systems to produce a set of symptoms that are often difficult to treat. Previous study indicates that saffron has anti-inflammatory properties that may be mediate by neurotransmitter system. In this study we determine the role of cannabinoids receptors in peripheral and central effects of Crocin on behav...
متن کاملmicroinjection of calcitonin in midbrain periaqueductal gray attenuates hyperalgesia in a chronic constriction injury rat model
objective(s): as heat, pain is one of the most common clinical symptoms. generally, calcitonin (ct) is prescribed as an analgesic agent for the treatment of pain, especially for the pain caused by osteoporosis or primary and metastatic bone tumor. however, the detailed mechanism remains unknown.materials and methods: in this study, chronic constriction injury (cci) rat model was created, and ho...
متن کاملP68: Effects of Saffron Extract and its Active Constituent Crocin on Development of Neuropathic Pain in a Rat Model of Chronic Constriction Injury
Neuropathic pain is caused by a lesion or disease affecting the nervous systems, and is generally manifested as spontaneous pain, hyperalgesia, and allodynia. Previous study indicate that saffron has anti-inflammatory and antioxidant properties, we investigated whether saffron and crocin, a major constitute of saffron, would infleuence on behavioral responses of pain induced by chronic constric...
متن کاملEffects of Saffron (Crocus sativus L.) Stigma Extract and its ActiveConstituent Crocin on Neuropathic Pain Responses in a Rat Model of Chronic Constriction Injury
This study was designed to investigate the therapeutic effects of saffron (Crocus Sativus L) and its main constituent crocin on neuropathic pain behavioral responses induced by chronic constriction injury (CCI) in rats. Adult male Wistar rats (200 to 250 g) were randomly assigned into 5 groups: Sham + saline, CCI + saline, CCI+ saffron (30 mg/kg), CCI +crocin (15 mg/kg) and CCI + crocin (30 mg/...
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ژورنال
عنوان ژورنال: Pain
سال: 2019
ISSN: 0304-3959,1872-6623
DOI: 10.1097/j.pain.0000000000001569